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Identification of gene targets of developmental neurotoxicity focusing on DNA hypermethylation involved in irreversible disruption of hippocampal neurogenesis in rats.
Kikuchi S, Takahashi Y, Ojiro R, Takashima K, Okano H, Tang Q, Woo GH, Yoshida T, Shibutani M. Kikuchi S, et al. J Appl Toxicol. 2021 Jul;41(7):1021-1037. doi: 10.1002/jat.4089. Epub 2020 Nov 4. J Appl Toxicol. 2021. PMID: 33150595 Free PMC article.
Herein, we searched for genes with hypermethylated promoter region and downregulated transcript level to reveal irreversible markers of developmental neurotoxicity. The hippocampal dentate gyrus of male rat offspring exposed maternally to PTU, VPA, or GLY was subjected to …
Herein, we searched for genes with hypermethylated promoter region and downregulated transcript level to reveal irreversible markers of deve …
Aberration in epigenetic gene regulation in hippocampal neurogenesis by developmental exposure to manganese chloride in mice.
Wang L, Shiraki A, Itahashi M, Akane H, Abe H, Mitsumori K, Shibutani M. Wang L, et al. Toxicol Sci. 2013 Nov;136(1):154-65. doi: 10.1093/toxsci/kft183. Epub 2013 Aug 23. Toxicol Sci. 2013. PMID: 23976782
By CpG promoter microarray analysis on PND 21 following 800-ppm Mn exposure, sustained promoter hypermethylation and transcript downregulation through PND 77 were confirmed with Mid1, Atp1a3, and Nr2f1, whereas Pvalb showed a transient hypermethylation only on weaning. The …
By CpG promoter microarray analysis on PND 21 following 800-ppm Mn exposure, sustained promoter hypermethylation and transcript downregulati …
Relationship between brain accumulation of manganese and aberration of hippocampal adult neurogenesis after oral exposure to manganese chloride in mice.
Kikuchihara Y, Abe H, Tanaka T, Kato M, Wang L, Ikarashi Y, Yoshida T, Shibutani M. Kikuchihara Y, et al. Toxicology. 2015 May 4;331:24-34. doi: 10.1016/j.tox.2015.02.005. Epub 2015 Feb 16. Toxicology. 2015. PMID: 25698507
Brain Mn accumulation in 56-day exposed cases, as well as in directly Mn-injected cases occurred in parallel with reduction of Pvalb(+) GABAergic interneurons in the dentate hilus, suggesting that this may be responsible for aberrant neurogenesis. For reduction of Pvalb …
Brain Mn accumulation in 56-day exposed cases, as well as in directly Mn-injected cases occurred in parallel with reduction of Pvalb( …